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Nanoparticle albumin bound paclitaxel (nab-PTX) is widely used in the clinic to treat different cancers, but the effect of albumin on the distribution of the drug in tumours is not clear. Here the authors show that the accumulation of nab-PTX in tumo ...
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In organic chemistry, synthetic routes for new molecules are often specified in terms of reacting molecules only. The current work reports an artificial intelligence model to predict the full sequence of experimental operations for an arbitrary chemi ...
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A longitudinal analysis of humoral immune responses in patients with COVID-19 with varying disease severities reveals that mortality does not correlate with antiviral antibody levels but, instead, with slower seroconversion.
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Carbon loss from forests occurs through deforestation or the degradation of existing forest. The loss of forest area in the Brazilian Amazon was higher in 2019 than following drought and an El Niño event in 2015, yet degradation drove three times ...
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Takeuchi et al perform cross-sectional and longitudinal analyses of associations between childhood socioeconomic status and psychometric intelligence as well as microstructural brain development in Japanese children. They report that higher socioecon ...
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In this placebo-controlled trial, 10/13 malaria naïve subjects immunized with a simplified regimen of chemoattenuated P. falciparum sporozoites, PfSPZ-CVac, show sterile protection from heterologous malaria challenge. Immunization was well tolerat ...
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Radar measurements obtained between 2006 and 2020 determine fundamental parameters of Venus, including its spin axis precession, moment of inertia and amplitude of length-of-day variations. Observed length-of-day variations are attributed to approxim ...
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Microplastic pollution is a major threat to marine food webs, but the wider ranging impacts on global ocean biogeochemistry are poorly understood. Here the authors use an Earth system model to determine that zooplankton grazing on microplastics could ...
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Improving the efficiency of carbon yield in heterotrophic microorganisms is desired for biomanufacturing. Now, a product-independent and energy-efficient CO2 sequestration system that maximizes carbon conversion has been developed, as showcased by th ...
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The most parsimonious network of routes taken by the first people navigating Sahul emerge from landscape-based rules, which can also be applied to other peopling events, to quantify the likely patterns of the peopling of Earth.